# Experiment #12: Kynurenine Pathway Dysregulation in HD — KMO, IDO1, and QUIN/KYNA Imbalance

**Date:** October 04, 2026
**Model:** not run
**Version:** 1
**First run:** October 04, 2026, no model called

## Hypothesis

The checked-in script states a research question. That question is not a result of this run:

1. How well does QUIN/KYNA imbalance explain MSN/SPN vulnerability in HD striatum? 2. Can KMO inhibition (CHDI-00340246, Ro61-8048) reduce HD pathology independently of mHTT lowering? 3. Is IDO1 inhibition (epacadostat repurposing) tractable for HD neuropsychiatric symptoms? 4. Does kynurenine pathway dysregulation interact with other HD mechanisms (NAD+/h021, neuroinflam/h001)?

## Method

Confirmed `src/run_experiment_12_kynurenine_pathway.py` is present and that no results file for experiment 12 existed before this write-up. The script describes a PubMed-to-local-LLM pipeline. It was not executed. `llm_blocker()` returned: Blocked: Ollama is not reachable at http://localhost:11434 (ConnectionError). Set OLLAMA_BASE_URL to a running server, or set GEMINI_API_KEY (or GOOGLE_API_KEY) with HD_LLM_BACKEND=aistudio. No model output was generated.

## Result

No papers were fetched for this experiment. No model was called. No scores, rankings, or biological findings were computed. The finished outcome is that the run is blocked before data collection.

## Log

- Script present: yes
- Prior result artifact: none
- Model calls: 0
- Papers fetched by this run: 0

updated by writing a finished account of the unexecuted script. No findings were invented.