# Experiment #16: Mitochondrial Membrane Stabilization in HD

**Date:** October 04, 2026
**Model:** not run
**Version:** 1
**First run:** October 04, 2026, no model called

## Hypothesis

The checked-in script states a research question. That question is not a result of this run:

1. Is Complex II (succinate dehydrogenase) loss a driver or consequence of mHTT toxicity? 2. Does cardiolipin disruption precede or follow mHTT aggregation in HD neurons? 3. What is the therapeutic window for elamipretide (SS-31) in HD striatum? 4. How does inner mitochondrial membrane (IMM) stabilization compare to NAD+ restoration (h021)? 5. Can combining IMM stabilization (elamipretide) with NAD+ precursors (NR/NMN) rescue energy failure?

## Method

Confirmed `src/run_experiment_16_mitochondrial_membrane.py` is present and that no results file for experiment 16 existed before this write-up. The script describes a PubMed-to-local-LLM pipeline. It was not executed. `llm_blocker()` returned: Blocked: Ollama is not reachable at http://localhost:11434 (ConnectionError). Set OLLAMA_BASE_URL to a running server, or set GEMINI_API_KEY (or GOOGLE_API_KEY) with HD_LLM_BACKEND=aistudio. No model output was generated.

## Result

No papers were fetched for this experiment. No model was called. No scores, rankings, or biological findings were computed. The finished outcome is that the run is blocked before data collection.

## Log

- Script present: yes
- Prior result artifact: none
- Model calls: 0
- Papers fetched by this run: 0

updated by writing a finished account of the unexecuted script. No findings were invented.