# Experiment #17: PDE10A Inhibitors — Striatal cAMP/cGMP Rescue in HD

**Date:** October 04, 2026
**Model:** not run
**Version:** 1
**First run:** October 04, 2026, no model called

## Hypothesis

The checked-in script states a research question. That question is not a result of this run:

1. Is PDE10A loss in HD striatum a driver of MSN dysfunction or a downstream consequence? 2. Do PDE10A inhibitors restore DARPP-32/CREB/PGC-1α signaling in HD preclinical models? 3. What is the presymptomatic therapeutic window for PDE10A targeting in HD? 4. How does the cAMP/cGMP axis interact with existing hypotheses (h020 MSN excitability, h021 NAD+/SIRT1, h037 BDNF/TrkB)? 5. Can PDE10A PET imaging serve as a progression biomarker for HD clinical trials?

## Method

Confirmed `src/run_experiment_17_pde10a_striatal_rescue.py` is present and that no results file for experiment 17 existed before this write-up. The script describes a PubMed-to-local-LLM pipeline. It was not executed. `llm_blocker()` returned: Blocked: Ollama is not reachable at http://localhost:11434 (ConnectionError). Set OLLAMA_BASE_URL to a running server, or set GEMINI_API_KEY (or GOOGLE_API_KEY) with HD_LLM_BACKEND=aistudio. No model output was generated.

## Result

No papers were fetched for this experiment. No model was called. No scores, rankings, or biological findings were computed. The finished outcome is that the run is blocked before data collection.

## Log

- Script present: yes
- Prior result artifact: none
- Model calls: 0
- Papers fetched by this run: 0

updated by writing a finished account of the unexecuted script. No findings were invented.