# Experiment #18: GLP-1R Agonists — Neuroprotection Repurposing for HD

**Date:** October 04, 2026
**Model:** not run
**Version:** 1
**First run:** October 04, 2026, no model called

## Hypothesis

The checked-in script states a research question. That question is not a result of this run:

1. What is the evidence for GLP-1R expression and function in HD-vulnerable circuits (striatum, cortex, hippocampus)? 2. Do GLP-1R agonists (exendin-4, liraglutide, semaglutide) reduce neurodegeneration in HD mouse models — and via which pathways? 3. How does the SPARK trial (lixisenatide in PD, Lancet 2024) de-risk the HD repurposing

## Method

Confirmed `src/run_experiment_18_glp1r_neurodegeneration.py` is present and that no results file for experiment 18 existed before this write-up. The script describes a PubMed-to-local-LLM pipeline. It was not executed. `llm_blocker()` returned: Blocked: Ollama is not reachable at http://localhost:11434 (ConnectionError). Set OLLAMA_BASE_URL to a running server, or set GEMINI_API_KEY (or GOOGLE_API_KEY) with HD_LLM_BACKEND=aistudio. No model output was generated.

## Result

No papers were fetched for this experiment. No model was called. No scores, rankings, or biological findings were computed. The finished outcome is that the run is blocked before data collection.

## Log

- Script present: yes
- Prior result artifact: none
- Model calls: 0
- Papers fetched by this run: 0

updated by writing a finished account of the unexecuted script. No findings were invented.