# Experiment #21: cGAS-STING Innate Immune Pathway in HD

**Date:** October 04, 2026
**Model:** not run
**Version:** 1
**First run:** October 04, 2026, no model called

## Hypothesis

The checked-in script states a research question. That question is not a result of this run:

Does mHTT-driven mitochondrial DNA (mtDNA) release activate the cGAS-STING innate immune axis in HD striatal neurons, and can STING inhibitors suppress the resulting type I interferon neuroinflammatory cascade to slow HD neurodegeneration?

## Method

Confirmed `src/run_experiment_21_cgas_sting_innate_immunity.py` is present and that no results file for experiment 21 existed before this write-up. The script describes a PubMed-to-local-LLM pipeline. It was not executed. `llm_blocker()` returned: Blocked: Ollama is not reachable at http://localhost:11434 (ConnectionError). Set OLLAMA_BASE_URL to a running server, or set GEMINI_API_KEY (or GOOGLE_API_KEY) with HD_LLM_BACKEND=aistudio. No model output was generated.

## Result

No papers were fetched for this experiment. No model was called. No scores, rankings, or biological findings were computed. The finished outcome is that the run is blocked before data collection.

## Log

- Script present: yes
- Prior result artifact: none
- Model calls: 0
- Papers fetched by this run: 0

updated by writing a finished account of the unexecuted script. No findings were invented.