Collaborate on open HD R&D
This is an open research project. Everything, the experiments, the code, the data pipeline, the hypotheses, is public and forkable. Here are concrete ways to work together, and how to start.
Ways to collaborate
Reproduce or critique an experiment
Every experiment ships its code, prompts, and data. Re-run it, challenge the method, or flag where the AI got something wrong. Skeptical review is the highest-value contribution.
Test a falsifiable hypothesis
We turn AI ideas into concrete, testable predictions (e.g. the chorea-footwear margin-of-stability claim). If you have a lab or cohort, try to break one.
Contribute a data source or an agent
Add a feed (a registry, a dataset, a scanner) or a new autonomous agent to the pipeline. Everything that lands feeds the shared knowledge base.
Co-design an experiment
Bring a question. We'll help scope it into a reproducible run (search → analyze → score → honest write-up), and publish it with your framing.
Validate in a lab or cohort
Take a computational hypothesis into the real world, wet-lab, gait lab, or an HD cohort (e.g. via Enroll-HD / CHDI / an HDSA Center of Excellence). Pre-registration welcome.
Lend lived experience
Patients, families, and caregivers: tell us what actually matters day to day. It should shape what we prioritize. For care, always start with your clinician and HDSA.
How it works
- 1Start a conversation. Open a GitHub Discussion or reach out on LinkedIn with what you'd like to do, no formal proposal needed.
- 2Scope it together. We turn it into a small, concrete, reproducible piece of work with a clear question and an honest success criterion.
- 3Build in the open. Code and data are public. You keep authorship of your framing; the AI's role is always labeled.
- 4Publish honestly. Every result says what worked and what didn't, with limitations and how to reproduce it. No hype.
What we bring to the table
Ready when you are
Pick any of the above, or bring your own. The fastest start is a GitHub Discussion, we'll take it from there.
Open research collaboration for education and discovery, not a company, a partnership offer, or medical advice. AI-generated outputs are unvalidated hypotheses for expert review. We are data scientists, not doctors. For HD care, contact HDSA (hdsa.org) or your clinician.