Experiment #22 · October 4, 2026 · version 1 · first run, no model
Adenosine A2A Receptor Antagonism for HD MSN Protection
Hypothesis
The script states this question. It was not tested here: 1. What is the mechanistic basis for A2A receptor overactivation in HD striatal MSNs? 2. Does istradefylline rescue HD phenotypes in R6/2 or zQ175 models? 3. What is the A2AR-cAMP-PKA-BDNF signaling cascade in MSN vulnerability? 4. How does A2A antagonism compare with or complement PDE10A inhibition? 5. Is there epidemiological evidence linking caffeine intake to delayed HD onset? 6. What is the druggability and CNS pharmacology of A2A antagonists? 7. Are there HD-specific A2A receptor expression changes in post-mortem brain? 8. What combination strategies (A2A + PDE10A, A2A + NR) might synergize?
Method
Checked that run_experiment_22_adenosine_a2a_msnprotection.py exists and was not run. No local Ollama server and no Gemini key were available, so the script was not started.
Result
No papers, scores, or biological findings. This run stops at the blocker.
Full write-up: data/experiment_022_blocked_report.md.
updated by recording the blocked run instead of leaving the script unpublished and empty.