HD Research Hub

Experiment #23 · October 4, 2026 · version 1 · first run, no model

Thiamine + Biotin TCA Cycle Rescue in HD

Hypothesis

The script states this question. It was not tested here: Can high-dose thiamine and biotin restore TCA cycle enzyme activity in HD striatum, and what is the mechanistic overlap with BTBGD?

Method

Checked that run_experiment_23_thiamine_biotin_tca_rescue.py exists and was not run. No local Ollama server and no Gemini key were available, so the script was not started.

Result

No papers, scores, or biological findings. This run stops at the blocker.

Full write-up: data/experiment_023_blocked_report.md.

updated by recording the blocked run instead of leaving the script unpublished and empty.

Research log