Experiment #16 · October 4, 2026 · version 1 · first run, no model
Mitochondrial Membrane Stabilization in HD
Hypothesis
The script states this question. It was not tested here: 1. Is Complex II (succinate dehydrogenase) loss a driver or consequence of mHTT toxicity? 2. Does cardiolipin disruption precede or follow mHTT aggregation in HD neurons? 3. What is the therapeutic window for elamipretide (SS-31) in HD striatum? 4. How does inner mitochondrial membrane (IMM) stabilization compare to NAD+ restoration (h021)? 5. Can combining IMM stabilization (elamipretide) with NAD+ precursors (NR/NMN) rescue energy failure?
Method
Checked that run_experiment_16_mitochondrial_membrane.py exists and was not run. No local Ollama server and no Gemini key were available, so the script was not started.
Result
No papers, scores, or biological findings. This run stops at the blocker.
Full write-up: data/experiment_016_blocked_report.md.
updated by recording the blocked run instead of leaving the script unpublished and empty.